A family of liver enzymes, the Cytochrome P450 (CYP450) enzymes, are involved in the metabolism of about 80% of all pharmaceutical drugs. Before prescribing a drug to you, your physician may want to know about your genetic makeup, and may use this information when establishing your treatment.
The CYP450 genes 2C19, 2C9, 2D6, 3A4, and 3A5 are involved in processing many drugs, including: Plavix, Coumadin, Beta Blockers, Statins, Pain Medications, and Anti-Depressants to name just a few.
Different variations in gene coding have profound effects on the enzymes in your body, which determines your ability to effectively metabolize medications. Testing provides your physician with your valuable genetic information regarding these enzymes, to determine your ability to process the drug and if you will respond to treatment normally. The result is that you are prescribed medicines that are best suited for you; minimizing complications and risk related to metabolism of medications.
“Given this variation in the human genome, the metabolism and hence, the final plasma concentration of drugs (drug response) is to a large extent determined by our genetic makeup. Based on this information, the FDA currently recommends the use of genetic information for drug dosing in about 120 drugs via a black-box warning. The FDA believes that these recommendations will improve the care of patients and are based on solid evidence.”
DR. KARTHIK "KASI" KASIRAJAN
Chief Medical Officer (Natural Molecular Testing Corp.)
The FDA has recommended genetic testing for many medications and categorized the metabolic status of enzymes related to the effectiveness of these medications. For example, if the genetic test determines you are a 'poor metabolizer' of a certain drug this may affect your physician's choice of optimal dosing for certain drugs or the choice of an alternative treatment.